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LERK2

[Ligand of eph-related kinase-2] Human and rat LERK2 are type 1 transmembrane proteins and show 95 % identity at the protein level. Soluble forms also exist. LERK2 is the same as Ephrin B1 (see also: ephrins).

LERK2 has been shown to bind to HEK2 [human embryo kinase-2] (see: HEK). Membrane-bound LERK2 ligand has been shown also to signal through Cek5, Cek10 and Elk but not with Cek9 receptor. Cek10 appears to be the preferred LERK2 receptor.

Coincubation of cells expressing HEK2 and LERK2 induces cell-cell adhesion and formation of cell aggregates ... ... ... ... ... Subscribe to continue reading! ... ...

 

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