Lem |
Leman coiled-coil protein |
FBCs |
||
[Lymphocyte Expansion Molecule] This mouse protein has been identified by Okoye et al (2015) by virtue of its ability to promote antigen-dependent CD8(+) T-cell proliferation, effector cell function, and memory cell generation in response to infection with human lymphocytic choriomeningitis virus, which is known to cause deletion and immune exhaustion of cytotoxic T-cells and a block in memory CD8 T-cell development. Upregulation of LEM in mutant mice, termed Retro, show restored cytotoxic T-cell immunity to chronic viral infection and tumor challenge and also increased memory cell development.
The human
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |