L138.8A
A mouse bone marrow-derived factor-dependent cell line with characteristics of mast cells (see also: Factor-dependent cell lines). This cell line responds to IL3, IL4, or IL9 and can be used in bioassays for these factors. The cells secrete IL6 into the conditioned medium in response to all three factors, with IL9 being the most potent inducer.
SCF induces synthesis of various chymases and tryptases (MMCP-4, MMCP-6, MMCP-7) and increases the fraction of cells expressing kit and Fc-epsilon R1
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