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[L Star protein; Theiler's virus L* protein] This membrane-associated 18 kDa protein is encoded by an alternative open reading frame in the genome of the picornavirus Theiler's murine encephalomyelitis virus (TMEV) (Roos et al, 1989). Subgroups of this virus are less virulent and induce a chronic demyelinating disease that serves as an experimental model of multiple sclerosis (Brahic et al, 2005). Viruses with a mutation of L* have a dramatically decreased demyelinating activity (Chen et al, 1995). L* protein is a key determinant required for the cell-type-specific restriction of virus growth in macrophages and microglial cells
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