kuz |
Kuzbanian homolog |
cytomegalovirus inhibitor of RIP-mediated signaling |
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The Drosophila melanogaster kuzbanian (kuz) gene (CG7147) is expressed in the nervous system. It encodes a member of the zinc metalloproteinases with a disintegrin domain and the protein thus is a member of the ADAM protein family. The protein is highly conserved and is closley related to the TNF-alpha converting enzyme (TACE). The mammalian homolog is ADAM10 [a disintegrin and metalloprotease domain 10].
The protein is essential for the partitioning of neural and nonneuronal cells during development of both the central and peripheral nervous systems in Drosophila melanogaster
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