KG-1

A human acute myeloid leukemia cell line established from a patient with acute myelogenous leukemia that had evolved from an erythroleukemia. It represents an early stage of hematopoietic differentiation (see also: hematopoiesis).

A subline of KG-1, designated KG1a, has lost myeloid features, acquired new karyotypic markers, and has several characteristics associated with immature T-cells. The cells are deficient in human p53. Both KG-1 and KG1a transcribe unrearranged IgH genes. Shmelkov et al (2001) have used a two-dimensional Gene Expression Fingerprinting to compare the gene expression ... ... ... ...
 
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Entry last modified: January 2002