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Jagged-2

The cDNA for this gene has been assembled by Luo et al (1997) from from overlapping cDNA clones isolated from human expressed sequence tag sequences resembling that of Serrate (see: jagged), the gene for a ligand of Drosophila melanogaster Notch. Deng et al (2000) have mapped the human gene (30 kb; 26 exons) to chromosome 14q32. The approved gene symbol is JAG2. The gene is known also as SER2 [serrate-2].

In the mouse, Jagged-2 mRNA is most abundant in heart, lung, thymus, skeletal muscle, brain, and testis. Jagged-2 is coepressed together with Notch-1 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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