ING5

[inhibitor of growth 5] This putative tumor suppressor gene has been cloned by Shiseki et al (2003), who called it p28ING5. Shiseki et al (2003) have shown that overexpression of ING4 in cancer cell lines diminishes colony-forming efficiency, decreases cell population in S phase, and induces p53-dependent cell death by apoptosis.

Doyon et al (2006) have reported that ING5 forms complexes with histone acetyltransferases containing HBO1 or nucleosomal H3-specific MOZ/MORF. These complexes interact with the MCM helicase and are essential for DNA replication to occur during the S phase of the cell cycle ... ... ... ...
 
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Entry last modified: March 2006