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IL12-p40

the p40 (40 kDa) subunit of IL12. This protein also forms biologically active homodimers. The p40 subunit of IL12 is also a component of IL23 and is therefore also being referred to as IL23-p40. Some cells such as macrophages and microglial cells have been shown to produce specifically the IL12-p40 subunit, but not IL12, under certain conditions (Constantinescu et al, 1996; Mottonen et al, 2002; Fernandez-Lago et al, 1999).

The p40 subunit of murine IL12 has been shown to specifically antagonize the effects of the biologically active IL12 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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