ICH-2

[ICE and CED3 homolog-2] ICH-2 is a human gene encoding a member of the IL1-beta Convertase (ICE) cysteine protease family (Kamens et al, 1995). ICH-2 mRNA is expressed widely in human tissues in a pattern similar to, but distinct from, that of ICE. Overexpression of ICH-2 in insect cells induces cell death by apoptosis. ICH-2 and ICE share catalytic properties but may differ in substrate specificities, suggesting that the two enzymes have different functions in vivo.

ICH-2 is a member of the family of caspases, which play a central role in cell death by apoptosis. It has been suggested that ICH-2 be ... ... ... ...
 
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Entry last modified: June 2003