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Hepatitis C virus NS4B protein

[Hepatitis C virus nonstructural protein 4B; HCV NS4B protein; NS4B protein] This protein is a non-structural protein contained within the viral polyprotein encoded by the genome of the positive-strand RNA virus Hepatitis C virus.

NS4B is localized to the endoplasmic reticulum. Self-oligomerization leads to the formation of multi-vesicular structures around endoplasmic reticulum membranes and creates a membranous web that is necessary for the formation of viral replication complexes (Paul et al, 2011). Disruption of NS4B dimerization/multimerization as well as its interaction with NS5A protein suppresses viral genome replication (Choi et al, 2013). Liu et al (2005) have identified RTN3 [reticulon-3] as a protein interacting with NS4B in hepatocytes ... ... ... ... ... Subscribe to continue reading! ... ...


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