HKH20
HKH20 is a 20-mer peptide (HKHGHGHGKHKNKGKKNGKH) that corresponds to residues His479-His498 of the D5 region of kininogen (KNG1) (Nordahl et al, 2005) (see also: Kininostatin). HKH17 (HKHGHGHGKHKNKGKKN) is a truncated derivative (Nordahl et al, 2005). For a truncated form, KNK10 (KNKGKKNGKH), see also: GKH17.
The HKH20 peptide has been shown to bind to endothelial cells (Hasan et al, 1995), inhibits the procoagulant activity of plasma high molecular weight kininogen, interferes with the assembly and activation of enzymes of the contact phase system of coagulation (plasma
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