HIN-1

[high in normal-1] HIN-1 has been identified as a gene the expression of which is downregulated significantly in >90 % of human breast carcinomas and preinvasive lesions. HIN-1 is a secreted protein highly expressed in normal breast epithelium and downregulated in breast carcinomas.

The authors describe HIN-1 as a putative cytokine with no significant homology to known proteins. HIN-1 inhibits cell growth of into breast cancer cells engineered to produce the protein.

The protein is related to uteroglobin and has been referred to as UGRP2 [Uteroglobin-related protein 2] by Niimi et al (2002), who cloned the murine gene (For a related protein see also ... ... ... ...
 
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Entry last modified: January 2008