HIAF-1

[human inhibitor angiogenesis factor-1] The cDNA for this factor has been cloned from human fetal liver tissue (Guo et al, 2000). The sequence appears to be a C-terminal fragment of human collagen type 18 and is thus identical with Endostatin.

The factor inhibits proliferation of endothelial cells in vitro. In vivo (transplanted tumors in a mouse model) the factor blocks growth and metastasis of tumors by blocking tumor angiogenesis.

See also: Angiogenesis Dictionary section of this encyclopedia for other entries directly bearing on factors and processes involved in the generation of new blood vessels.

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Entry last modified: April 2002