Endostar |
Endostatin 15 |
MCL1S |
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This factor of 20 kDa (183 amino acids) is found in the conditioned medium of the hemangioendothelioma cell line EOMA. The endostatin fragment of collagen type 18 has been identified independently as HIAF-1. Endostatin has been identified as a fragment of the non-triplehelical C-terminal NC1 domain of collagen type 18 (collagen-18-alpha-1 NC1 domain; abbr. also: alpha1(XVIII)NC1) (O'Reilly et al, 1997) and has been referred to as endostatin 18 (endostatin XVIII) (Sasaki et al, 2000). For two extended forms of endostatin (termed neostatin-7 and neostatin-14 see:
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