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HELAD1

[helicase, APC down-regulated 1] The gene encoding this protein has been identified by Ishiguro et al (2002). Its expression is regulated by the adenomatous polyposis coli gene product. Expression is observed 16 of 20 colon cancers examined but hardly detectable in corresponding non-cancerous mucosae. Treatment of colon cancer cells with antisense oligonucleotides suppresses expression of HELAD1 and induced cell death by apoptosis. HELAD1 has been shown to possess 3' to 5' helicase activity and exonuclease activity in vitro.

Sequence analysis shows that HELAD1 is identical with NAV2 [neuron navigator 2].

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