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HAI-1

abbr. also HAI. [Hepatocyte growth factor activator inhibitor, HGF activator inhibitor type 1; HGFA inhibitor-1] This protein is an inhibitor of HGF activator, which is responsible for the proteolytic activation of HGF [hepatocyte growth factor] (For a second inhibitor see also: HAI-2).

The inhibitor has been isolated by Shimomura et al (1997) from the conditioned medium of the human MKN45 stomach carcinoma cell line. The sequence of the cDNA suggests that the inhibitor is a member of the Kunitz family of serine protease inhibitors (approved gene symbol: SPINT1 [ ... ... ... ... ... Subscribe to continue reading! ... ...

 

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