H 2 |
H2AFX |
immune-induced peptide 11 |
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[H2A histone family member B1]
This protein is a member of the H2A histone family. Gu et al (2010) have referred to H2AFB1, which they identified mainly in spermatocytes in mouse testis as TSEG-1 [testis specific expressed gene 1]. The surgical cryptorchidism mouse model shows an increase in the TSEG-1 expression, accompanied by enhanced cell death by apoptosis of spermatogenic cells. Forced expression of TSEG-1 in spermatocytes suppresses cell viability, increases apoptosis, and decreases mitochondrial membrane potential. Intratesticular injection of TSEG-1 increases apoptosis of
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