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Glypican-6

approved gene symbol: GPC6. Glypican-6 is one member of the family of heparan sulfate proteoglycans known as glypicans. Glypican-6 is related to Glypican-4 (63 % identity) (Veugelers et al, 1999). Prominent expression is seen in human fetal kidney and adult ovary and in mesenchymal tissues in the developing mouse embryo. High expression occur in smooth muscle cells lining the aorta and other major blood vessels and in mesenchymal cells of the intestine, kidney, lung, tooth, and gonad.

Glypican-6 is one of the most abundant ECM molecules in the brain. Salehi (2009) has reported that glypican-6 is important in vivo in regulating bFGF ... ... ... ... ... Subscribe to continue reading! ... ...

 

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