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GSM

[Glucocorticoid-suppressible mitogenic activity] This factor is found in the conditioned medium of a rat hepatoma cell line (subline BDS.1 of the Fu5 hepatoma cell line) which are hypersensitive to the antiproliferative effects of the glucocorticoid dexamethasone (Cook et al, 1989).

The GSM activity is secreted constitutively into the conditioned medium of EDR3 cells, a subline of Fu5 which is resistant to the antiproliferative effects of dexamethasone. GSM expression is suppressed by treatment of the cells with glucocorticoids.

GSM stimulates incorporation of tritiated thymidine in quiescent, serum-starved Balb/c 3T3 cells. GSM stimulates 3T3 cells ... ... ... ... ... Subscribe to continue reading! ... ...

 

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