GPR15 ligand |
GPR19 |
secreted frizzled-related protein 3 |
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[G-protein-coupled receptor 18] In databanks this G-protein-coupled receptor is known also as GPCRW. The gene encoding this receptor has been cloned by Ganz et al (1997) who localized the gene to human chromosome 13q32 and demonstrated that the receptor is expressed abundantly in testis and spleen with a lesser degree of expression in several other tissues associated with endocrine and immunologic/hematologic function.
Chiang et al (2015) have identified RvD2 [resolvin D2] as a GPR18 ligand (hence the designation RvD2 receptor, Resolvin D2 receptor), showing that it mediates the resolution of infections and organ protection. GPR18 is expressed on human
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