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GON-1

[Abnormal gonad development protein 1] a secreted protein from Caenorhabditis elegans belonging to the ADAMTS protein family of matrix metalloproteinases. The protein is closely related to mammalian ADAMTS20 and ADAMTS9 (Somerville et al, 2003). In the nematode, the protein is required for gonadal morphogenesis (Blelloch and Kimble, 1999; Blelloch et al, 1999; Somerville et al, 2003). Hesselson et al (2004) have reported that GON-1 and fibulin have antagonistic roles in control of organ shape and that human ADAMTS4 or ADAMTS9 can substitute for GON-1 in transgenic worms.

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