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FRP-1

[fusion regulatory protein-1] FRP-1 has been identified originally as a glycoprotein of 80 kDa that regulates fusion of cells induced by Newcastle disease virus. Monoclonal antibodies directed against the protein enhance the susceptibility of cells to fusion activity of Newcastle disease virus. (Ito et al, 1992). This protein also induces multinucleated giant cell formation of monocytes and cell fusion mediated by HIV gp160. FRP-1 is identical with an antigen recognized by monoclonal antibody 4F2 (Ohgimoto et al, 1995). Tsumura et al (1998) have shown that mouse alloantigen Ly10 is identical to murine FRP-1.

The new designation for this antigen is CD98.

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