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FISP

[IL4 induced secreted protein] The protein is the murine counterpart of IL24.

FISP (220 amino acids) is expressed and secreted selectively by Th2 T-helper cells (Schaefer et al, 2001). Expression of FISP in developing Th cells requires signaling through the IL4 receptor that is dependent on STAT6 as well as T-cell receptor signaling involving protein kinase C.

Sahoo et al (2008) have identified a splice variant of mouse FISP, designated FISP-sp, which lacks 29 nucleotides from the 5' end of exon 4 of FISP. Unlike FISP, FISP-sp does not induce growth inhibition and cell death ... ... ... ... ... Subscribe to continue reading! ... ...

 

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