FASTKD2

[FAS-activated serine-threonine kinase domain 2; FAST kinase domains 2]. The gene has been identified independently as KIAA0971. Ghezzi et al (2008) have identified nonsense mutations in FASTKD2 in an infantile mitochondrial encephalomyopathy associated with cytochrome C oxidase deficiency.

FASTKD2 is expressed ubiquitously, most strongly in skeletal muscle. A role in the regulation in mitochondrial apoptosis is suggested by experiments showing that mutant fibroblasts show decreased apoptosis after treatment with staurosporine.

Yeung et al (2011) have reported that knock-down of FASTKD2 expression prevents apoptosis of breast cancer cells elicited by ... ... ... ...
 
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Entry last modified: June 2014