F1L
[orf virus F1L protein] This gene is encoded by orf virus (gene ORFV059 in some isolates). F1L is a highly immunogenic envelope-associated structural protein. The gene has been cloned by Gallina et al (2004).
Scagliarini et al (2004) have reported that F1L plays a role in the early stages of virus infection. F1L is the major heparin binding protein of orf virus. The protein is involved in virus binding to the cells and orf virus is inhibited by the addition of soluble heparin in cell cultures.
The protein mediates inhibition of cell death by apoptosis (Wasilenko et al, 2003). F1L protein interacts with the pro-apoptotic protein
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