F1L |
F2-alpha receptor regulatory protein |
PrCR |
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[factor-2] This biochemically uncharacterized factor is produced by the human B-cell line, Karpas 160. Its synthesis can be enhanced by treatment of the cells with PMA (see also: Phorbol esters) or sodium butyrate. The factor of 10-14 and 60-70 kDa is cytotoxic for a number of human tumor cell lines, including the human erythroleukemic cell line K562, which does not respond to TNF.
The biological activity of F-2 cannot be neutralized by antibodies directed against TNF, TGF-beta, IFN-alpha and IFN-gamma. See also: F-1.
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