Erythropoiesis stimulating factor |
Erythropoietin |
IEX-1L |
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This factor was isolated from a an anephric patient with nearly normal hematocrit values (Congote et al, 1991). Its N-terminal sequence is identical that of human insulin-like growth factor-1 (see: IGF).
Erythropoietic factor and human recombinant IGF-1 stimulate erythroid colony formation in human bone marrow cultures (see also: Colony formation assay, LTMBC). The possibility therefore exists that IGF-1 can replace Epo (erythropoietin) as a stimulator of erythropoiesis in some patients with anemia and renal failure.
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