Epo
[erythropoietin] also abbr. Ep.
ALTERNATIVE NAMES
ECSA (erythroid colony stimulating activity);
ESF (erythropoiesis stimulating factor).
SOURCES
Epo is predominantly synthesized and secreted by tubular and juxtatubular capillary endothelial cells and interstitial cells of the kidney. Approximately 10-15 % of the total amount of Epo comes from extrarenal sources and is predominantly produced by hepatocytes and Kupffer cells of the liver.
In the fetus the liver is the main source of Epo. It appears that the switch in the synthesis from liver to kidney which takes place after birth is genetically determined. The synthesis of
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