EmRK2
[Embryonic receptor kinase-2] The gene encoding this kinase has been isolated from embryoid bodies generated by differentiating embryonic stem cells Choi et al, 1994).
Sequence analysis of the cDNA predicts a receptor with a 755 amino acid extracellular region with seven immunoglobulin-like domains, a transmembrane region, and a 552 amino acid cytoplasmic region containing the kinase domain. The kinase domain is interrupted by a stretch of hydrophilic amino acids, the kinase insert (see: PTK (protein tyrosine kinase).
EmRK2 is expressed in embryoid bodies, in whole embryos at day 10 and 12 of gestation, and in the embryonic yolk sac and the fetal liver.
EmRK2 and
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