ELCs |
ELDIF |
NY-REN-11 |
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[Eosinophilic leukemia cell differentiation factor] This biochemically uncharacterized factor of approximately 30-40 kDa (gel filtration) is found in the conditioned medium of a human adult T-cell leukemia cell line (HIL-3).
ELDF is a glycoprotein but glycosylation does not appear to be essential for biological activity. ELDF induces differentiation of the human eosinophilic leukemia cell line EoL-1, causing the expression of eosinophilic granules and segmented nuclei. It also induces expression of CD23 and expression of a differentiation antigen of eosinophils, EO-1. The factor also induces EoL-1
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