EDMF

[Endothelioma-derived motility factor] This biochemically uncharacterized factor of 40-65 kDa has been found in the conditioned medium of murine endothelioma cell lines transformed by polyoma virus middle T.

These tumors are used as models for studying vascular lesions such as hemangiomas, hemangiosarcomas, and Kaposi sarcoma and tumor-associated angiogenesis because they produce fast-growing, hemorrhaging, cavernous blood-filled hemangiomas, mainly formed by recruited host endothelial cells.

EDMF stimulates Chemotaxis, haptotaxis, and chemoinvasion of normal human, bovine, and murine endothelial cells ... ... ... ...
 
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Entry last modified: January 2007