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ECF-A

[eosinophil chemotactic factor of anaphylaxis] This term has been used for the two tetrapeptides Ala-Gly-Ser-Glu (AGSE), and Val-Gly-Ser-Glu (VGSE) isolated from extracts and anaphylactic diffusates of human lung tissue and thought to be a product by mast cells and basophils. These two peptides are preferentially chemotactic for eosinophils in vitro (Goetzl and Austen, 1975). These two peptides are not classified as cytokines due to their small molecular weight (see also: regulatory peptide factors).

The term has been used indiscriminately for a variety of mediators.

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