E4orf4

This protein is encoded by the open reading frame 4 in the E4 region of the adenovirus genome. The protein cooperates with the viral E1A protein and promotes cell death by apoptosis in the absence of p53 (Marcellus et al, 1996). Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells (Shtrichman and Kleinberger, 1998) and requires an interaction with protein phosphatase 2A (Shtrichman et al, 1999). The protein activates caspase-8 and the FADD pathway in a cell line-specific manner (Livne et al, 2001).

For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary section of this encyclopedia. For other relevant entries see also the ... ... ... ...
 
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Entry last modified: June 2003