DRM

[Downregulated by mos; downregulated in mos-transformed cells] DRM is identical with Gremlin.

The DRM gene has been identified by Topol et al (1997), who compared, by differential display, the expression of RNA in v-mos transformed cells and their flat revertants. The expression of DRM is downregulated in the transformed cells and high in the revertants and normal rat fibroblasts (REF-1 cells). DRM gene expression is suppressed also in REF-1 cells transformed by v-ras, v-src, v-raf, and v-fos. Several lines of evidence suggest that cells expressing high levels of DRM undergo ... ... ... ...
 
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