DRAM1 |
dramatically shrunken and hyperbasophilic neurons |
FLICE-inhibitory proteins |
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(approved gene symbol) [DNA-damage-regulated autophagy modulator 2; damage-regulated autophagy modulator 2]. In databanks the protein is also named TMEM77 [transmembrane protein 77].
This protein is related to DRAM1 [DNA-damage-regulated autophagy modulator 1]. DRAM2 displays 45 % identity and 67 % conservation when compared to DRAM. DRAM2 is different from DRAM as it not induced by p53 or the p53-like transcription factor TP73 [tumor protein p73]. DRAM2 is also a lysosomal protein, but unlike DRAM its overexpression does not modulate autophagy. In contrast to humans, the Drosophila
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