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DEVD

The amino acid sequence Asp-Glu-Val-Asp (DEVD) corresponds to a sequence within PARP1 [poly(ADP-ribose) polymerase 1], a DNA repair enzyme. The sequence DEVD is cleaved by caspase-3 during cell death by apoptosis.

Derivatives of DEVD such as DEVD-AFC (conjugated to 7-amino-4-trifluoromethyl coumarin) or DEVD-AMC (conjugated to Amino-4-methyl coumarin) are used as fluorometric substrates for enzyme activity assays of caspases (caspase-3) which are detectable following cleavage of the substituted coumarin moiety from the peptide. DEVD-AMC is a substrate also of caspase-7 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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