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DEGA

[Differentially expressed in gastric adenocarcinomas] The cDNA has been identified by Rabenau et al (2004). It is a cell surface protein differentially expressed in human gastric adenocarcinomas with approximately 45 % of tumor cells from patients with gastric adenocarcinoma cells showing expression when compared with normal tissues. Stable expression of a DEGA antisense construct in a gastric adenocarcinoma cell line leads to altered morphology, increased ploidy, chromosomal instability, decreased cell adhesion and migration, and a nearly complete abrogation of tumorigenicity in nude mice.

The protein is identical with AMIGO2 and Alivin 1.

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