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DC-LAMP

[dendritic cell lysosome-associated membrane glycoprotein] The gene encoding this lysosome-associated membrane glycoprotein localized on chromosome 3q26.3-q27 has been identified by de Saint-Vis B et al (1998). DC-LAMP mRNA is present only in lymphoid organs and dendritic cells. A specific monoclonal antibody detects the protein exclusively in interdigitating dendritic cells. Expression of DC-LAMP increases progressively during in vitro dendritic cell differentiation, but sharply upon activation with LPS, TNF-alpha, or CD40L.

In the nomenclature of CD antigens this protein has been given the designation CD208.

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