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DAP-1

[Death associated protein 1] This is the same as DAP [death associated protein] (approved gene symbol). The gene encoding this protein was identified together with others (see: DAP-3, DAP-5) by screening cell populations transfected with an antisense cDNA library for their ability to survive in the continuous presence of IFN-gamma (Levy-Strumpf and Kimchi, 1998).

DAP-1 is a small proline-rich cytoplasmic protein of 15 kDa that functions as a mediator of cell death by apoptosis induced by IFN-gamma (Deiss et al, 1995). The human gene maps to chromosome 5p12.2 (Feinstein et al, 1995).

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Entry last modified: September 2015



 
 
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