DAD |
DADA2 |
E3-10.4 |
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[defender against apoptotic death; defender against cell death; defender against cell death 1] The gene encoding this protein has been identified by Nakashima et al (1993). The encoded protein rescues a temperature-sensitive mutant cell line that dies by apoptosis at the nonpermissive temperature and cannot be rescued by the apoptosis inhibitor protein BCL2.
DAD1 is a member of the BCL2 family of proteins. The protein is highly conserved between humans and hamsters (100 % amino acid identity) (Nakashima et al, 1993). The human gene maps to chromosome 14q11-q12 (Apte et al, 1995). The 12.5 kDa protein suppresses cell death by apoptosis in
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