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D-GADD45

[Drosophila GADD45] This protein, encoded by gene CG11086, is considered the sole Drosophila melanogaster ortholog of the three mammalian gadd45 [growth arrest and DNA damage induced gene-45] proteins. Unlike the mammalian three orthologs, D-GADD45 expression is not elevated following exposure to genotoxic and nongenotoxic agents in Schneider cells and in adult flies. Its transcript increases following immune response activation. Overexpression of D-GADD45 in various tissues leads to different phenotypic responses. Specifically, in the somatic follicle cells overexpression causes cell death by apoptosis ... ... ... ... ... Subscribe to continue reading! ... ...

 

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