CagA

[cytotoxin-associated gene A] In databanks the protein is being referred to also as cag26 [CAG pathogenicity island protein 26] or Cytotoxicity-associated immunodominant antigen.

This protein is encoded by strains of Helicobacter pylori that are highly associated with peptic ulcer disease and invasive gastric cancer (Perez-Perez et al, 1999). The protein is transferred to eukaryotic epithelial cells under the control of a variety of bacterial genes (Fischer et al, 2001) and is tyrosine-phosphorylated (Asahi et al, 2000). It modulates cellular functions. Churin et al (2003) have reported that CagA targets the HGF receptor (met) and enhances the motogenic response in cells ... ... ... ...
 
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Entry last modified: September 2006