CP-11C |
CP17 |
neuroleukin receptor |
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CP15 peptide, VHLGYAT, has been identified by phage display library screening (Zhang et al, 2007). It acts as a cell-targeting peptide and binds to colon cancer cells (SW480 and HT29 cells) and tumor tissues but not the normal human intestinal epithelial cells and control colon tissue (Zhang Y et al, 2007). In a mouse xenograft model of colon cancer developed from SW480 epithelial colon cancer cells, CP15-containing nanoparticles selectively target the tumor tissues and has been used to deliver siRNA directed towards serine/threonine-protein kinase PLK1, a key regulator of mitosis in mammalian cells and a proto-oncogene
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