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CKGGRAKDC

This peptide has been identified by Kolonin et al (2004) by phage display selection as a cell-targeting peptide that homes in to white fat vasculature. CKGGRAKDC peptide associates with the multifunctional membrane protein prohibitin, establishing prohibitin as a vascular marker of adipose tissue. A fusion construct containing CKGGRAKDC and the pro-apoptotic KLAKLAK sequence is targeted to prohibitin in the adipose vasculature and causes ablation of white fat. Resorption of established white adipose tissue and normalization of metabolism results in rapid obesity reversal without detectable adverse effects.

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