CIS homology domain |
cis-NATs |
trabecular meshwork cells |
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[cytokine-independent survival kinase] The gene has been cloned by Dai et al (1999), who referred to it as SGKL [Serum/glucocorticoid-regulated kinase-like]. The approved gene symbol is SGK3 [serum/glucocorticoid-regulated kinase family member 3].
This protein has been identified in a screen for factors that mediate IL3 dependent survival of hematopoietic cells (see also: factor-dependent cell lines). CISK is a serine threonine kinase, which contains a PX domain (phox homology domain) homologous to serum- and glucocorticoid-regulated protein kinase (SGK) (Liu et al, 2000). CISK is a downstream
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