CD59b

This designation has been given to a second mouse CD59 gene. Following identification of this separate CD59 gene CD59 has been renamed CD59a) (Qian et al, 2000).

Mouse CD59b is 85 % identical at the DNA level and 63 % identical at the amino acid sequence level to CD59a. CD59b encodes a GPI-anchored protein that is functionally active as a membrane attack complex inhibitor. CD59b is expressed selectively in the mouse testis. CD59a is expressed at high levels in the heart, kidney, liver, and lung, but only minimally in the testis. The genomic structure of both mouse ... ... ... ...
 
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Entry last modified: March 2012