CD40-binding protein |
CD40L |
zLEVD-fmk |
||
[CD40-binding protein] This protein was isolated by using a yeast two-hybrid screen which facilitates detection of proteins that interact with each other (Hu et al, 1994).
CD40BP interacts directly with the cytoplasmic tail of the cell surface antigen CD40 on B-cells through a region of similarity to TRAF proteins (TRAF domain), a protein family associated with the TNF-alpha receptor.
The protein is known also as CRAF-1, CAP-1, or LAP1 and has been renamed TRAF3 (Tumor necrosis factor receptor-associated factor-3
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