CBEGF |
CBGF |
QSHLSLCRWCCNCCRSNKGC |
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[collagen binding fibroblast growth factor] A fusion protein consisting of a collagen binding domain derived from Clostridium histolyticum collagenase and bFGF fused to the N-terminus of this domain (Nishi et al, 1998). The protein binds tightly to insoluble collagen and stimulates the growth of BALB/c 3T3 fibroblasts as much as the unfused counterparts. CBFGF, but not bFGF, strongly stimulates the DNA synthesis in stromal cells at 5 days and 7 days after injection. The authors suggest that the collagen binding domain
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