C7

This murine protein is expressed in murine peritoneal macrophages after induction with bacterial lipopolysaccharides or interferons (Narumi and Hamilton, 1990). It is called also CRG-2 (see: CRGs [cytokine responsive genes].

C7 is related closely to the interferon induced protein IP-10, showing approximately 77 % homology if conservative amino acid changes are taken into account, and 67 % identity (Ohmorin and Hamilton, 1990). The approved gene symbol is CXCL10. The factor is known also as SCYB10.

This factor is known mainly because of its chemotactic activity. For an unrelated function as an antimicrobial peptide ... ... ... ...
 
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Entry last modified: March 2002